Denyce Wicht, PhD
Department of Chemistry and Biochemistry
Office: Archer Building, Rm. 613
Office Hours: T 10am-11:30am
W before noon by appointment (please schedule 24 hours in advance)
- PhD, Dartmouth College
BA, University of Vermont
Wellesley College, 2003-2005
Visiting Assistant Professor
General Electric Global Research Center, 2000-2002
Chemist; Polymer and Specialty Chemical Technologies
Massachusetts Institute of Technology, 1999-2000
Broadly speaking, my research interests involve understanding the mechanistic processes that cleave methyl group carbon bonds (–CH3) to high-valent main group elements, specifically silicon (Si) and sulfur (S).
I’m interested in silicon–carbon bonds (Si–CH3) of the molecule dimethylsilanediol (abbreviated DMSD, structure shown below) because this specific molecule has been detected in environmental matrices. One source of DMSD in the environment is from chemical additives in personal care and other down-the-drain household products. Because no naturally occurring organosilicon compounds have been reported, chemical species containing silicon–carbon bonds, such as DMSD, are anthropogenic. The impacts of organosilicon xenobiotics are not entirely clear, but there is evidence for Si–CH3 catabolism in mammals. The long-term goal of my research is the identification of a catalytic system that can efficiently break the Si–CH3 bonds of DMSD under mild conditions and physiological pH. Neither a chemical nor a biological catalytic system has yet been identified. The identification of a catalyst capable of breaking a Si–CH3 bond would be a significant advancement in the field and applicable to the design of systems engineered to treat environmental pollutants.
The other bond I’m interested in is the sulfur–carbon bond (S–CH3) of the molecule dimethylsulfone (abbreviated DMSO2, structure shown below). Unlike DMSD, DMSO2 is a naturally occurring molecule. This compound enters the terrestrial environment through the chemical oxidation of biogenic dimethylsulfide, a compound that plays a major role in the global sulfur cycle. Despite the natural deposition of an estimated 2-8 million tons of DMSO2 annually, DMSO2 has not directly been detected in soil environments. In nature, it is speculated that soil bacteria biodegrade DMSO2. Perhaps indirect evidence for DMSO2 deposition are reports of microorganisms isolated from soil that can utilize DMSO2 for growth and metabolism, but the complete biochemical reactions that DMSO2 undergoes have not been elucidated. An ongoing research interest of mine involves understanding the enzymatic pathways through which DMSO2 is used by microorganisms. Understanding how soil bacteria break the sulfur–carbon bond (S–CH3) in a naturally occurring molecule may provide insight into how to design a catalyst to break other methyl group carbon bonds (–CH3) to high-valent main group elements.
The structures of dimethylsilanediol (DMSD) and dimethylsulfone (DMSO2)
Wicht, D. K. Green Chemistry Essay: We’re Going to Need a Bigger Earth. In Chemistry for Changing Times, 12th Edition; Hill, J. W.; McCreary, T. W.; Kolb, D. K.; Eds.; Pearson Prentice Hall: Upper Saddle River, NJ, 2010; p 336.
O’Brien, K. E.; Wicht, D. K. A Greener Organic Chemistry Experiment: Reduction of Citronellal to Citronellol Using Poly(methylhydro)siloxane. Green Chemistry Letters and Reviews 2008, 1, 149-154.
Butts, M.; Cella, J.; Darkangelo-Wood, C.; Gillette, G.; Kerboua, R.; Leman, J.; Lewis, L.; Rubinsztajn, S.; Schattenmann, F.; Stein, J.; Wicht, D.; Rajaraman, S.; Wengrovius, J. Silicones. In Kirk-Othmer Encyclopedia of Chemical Technology, 5th edition. Seidel, A. Ed.; John Wiley & Sons, Inc: Hoboken, NJ, 2006; 22, 547-626.
Courses Taught at Suffolk University
CHEM 111/L111 - General Chemistry I and Lab
CHEM 112/L112 - General Chemistry II and Lab
CHEM 211/L211 - Organic Chemistry I and Lab
CHEM 212/L212 - Organic Chemistry II and Lab
CHEM L355 - Environmental Chemistry Lab
CHEM 375 - Transition Metal Chemistry
CHEM 390 - Advanced Organic Chemistry
CHEM 510 - Independent Study in Chemistry